{"id":8613,"date":"2020-03-28T12:14:53","date_gmt":"2020-03-28T17:14:53","guid":{"rendered":"http:\/\/richard.rathe.org\/?p=8613"},"modified":"2020-03-29T10:43:54","modified_gmt":"2020-03-29T15:43:54","slug":"the-us-covid19-pandemic-and-s-curves","status":"publish","type":"post","link":"https:\/\/redmangrove.org\/rathe.org\/richard\/2020\/the-us-covid19-pandemic-and-s-curves","title":{"rendered":"The US COVID19 Pandemic and S-Curves"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Around March 25 the US became the poster child for the <strong>COVID19 Pandemic<\/strong>. This graphic from the <a rel=\"noreferrer noopener\" aria-label=\"Financial Times Tracking Site (opens in a new tab)\" href=\"https:\/\/www.ft.com\/coronavirus-latest\" target=\"_blank\">Financial Times Tracking Site<\/a> tells the sad tale. America is again number one! =(<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"700\" height=\"504\" src=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/01-covid19-case-trajectories-march-27-2020.png\" alt=\"\" class=\"wp-image-8636\" srcset=\"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/01-covid19-case-trajectories-march-27-2020.png 700w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/01-covid19-case-trajectories-march-27-2020-150x108.png 150w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/01-covid19-case-trajectories-march-27-2020-347x250.png 347w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 984px) 61vw, (max-width: 1362px) 45vw, 600px\" \/><figcaption>source:ft.com<br \/><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Note that when<a href=\"http:\/\/richard.rathe.org\/2020\/the-approaching-covid19-pandemic\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\" I first blogged about COVID19 back on March 1st (opens in a new tab)\"> I first blogged about COVID19 back on March 1st<\/a> there were only 62 reported cases in the US!<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At the time I&#8217;m writing this, the <strong>State of Florida<\/strong> is just getting around to effective measures. The official count is currently only 2,900 cases but that is certainly <strong>off by a factor of ten or more!<\/strong> <em>(In the US we&#8217;ve done an appalling job<\/em><strong><em> <\/em><\/strong><em>of testing for and controlling exposure to infected people.)<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This graphic appeared on Twitter yesterday&#8230;<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"594\" height=\"680\" src=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/02-confirmed-covid19-cases-china-vs-usa-march-27-2020.jpg\" alt=\"\" class=\"wp-image-8616\" srcset=\"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/02-confirmed-covid19-cases-china-vs-usa-march-27-2020.jpg 594w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/02-confirmed-covid19-cases-china-vs-usa-march-27-2020-131x150.jpg 131w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/02-confirmed-covid19-cases-china-vs-usa-march-27-2020-218x250.jpg 218w\" sizes=\"auto, (max-width: 594px) 85vw, 594px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">It got me thinking&#8230; <em>wouldn&#8217;t it be more effective it it were inverted?<\/em> So I gave it a shot&#8230;<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"594\" height=\"680\" src=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/03-confirmed-covid19-cases-china-vs-usa-march-27-2020-inverted.jpg\" alt=\"\" class=\"wp-image-8617\" srcset=\"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/03-confirmed-covid19-cases-china-vs-usa-march-27-2020-inverted.jpg 594w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/03-confirmed-covid19-cases-china-vs-usa-march-27-2020-inverted-131x150.jpg 131w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/03-confirmed-covid19-cases-china-vs-usa-march-27-2020-inverted-218x250.jpg 218w\" sizes=\"auto, (max-width: 594px) 85vw, 594px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Doesn&#8217;t that look more intimidating?! Imagine the <strong>longest, steepest rollercoaster<\/strong> you&#8217;ve ever been on, or maybe <strong>falling off a cliff<\/strong>. (You&#8217;ll notice I also added an <strong>arrow<\/strong> to emphasize there is currently <strong>NO BOTTOM <\/strong>to this curve!)<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">S-Curves<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">This put me in mind of <strong>basic epidemiology<\/strong> from medical school and even well-taught high school biology. Every Epi textbook has a graphic that looks something like this&#8230;<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"594\" height=\"680\" src=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/04-classic-epidemic-s-curve.jpg\" alt=\"\" class=\"wp-image-8618\" srcset=\"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/04-classic-epidemic-s-curve.jpg 594w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/04-classic-epidemic-s-curve-131x150.jpg 131w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/04-classic-epidemic-s-curve-218x250.jpg 218w\" sizes=\"auto, (max-width: 594px) 85vw, 594px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">This is the classic &#8220;<strong>s-curve<\/strong>&#8221; of epidemic spread. Things start slowly, but quickly speed up due to <strong>exponential growth<\/strong>. Our trajectory in the first graphic is <strong>DOUBLING every 2-3 days!<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">At some point the <strong>curve flattens<\/strong> because public health efforts are working&#8211;or <em>all potential hosts are either infected or dead!!<\/em> The curve for <strong>China<\/strong> in the second graph is roughly s-shaped and they&#8217;ve successfully made it to the leveling off phase (for now).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some States are doing a better job at <strong>flattening the curve<\/strong> through common sense public health efforts. Compare the dark bars in this graphic. <a rel=\"noreferrer noopener\" aria-label=\"larger version (opens in a new tab)\" href=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/05-kentucky-tennessee-covid19-spread-march-2020.jpg\" target=\"_blank\">[Larger Version]<\/a> <strong>Kentucky<\/strong> (blue) took more aggressive steps earlier. Contrast this with <strong>Tennessee<\/strong> (orange), which by March 20th had over <strong>four times<\/strong> more confirmed cases!<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"933\" height=\"553\" src=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/05-kentucky-tennessee-covid19-spread-march-2020.jpg\" alt=\"\" class=\"wp-image-8630\" srcset=\"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/05-kentucky-tennessee-covid19-spread-march-2020.jpg 933w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/05-kentucky-tennessee-covid19-spread-march-2020-150x89.jpg 150w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/05-kentucky-tennessee-covid19-spread-march-2020-400x237.jpg 400w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/05-kentucky-tennessee-covid19-spread-march-2020-768x455.jpg 768w\" sizes=\"auto, (max-width: 709px) 85vw, (max-width: 909px) 67vw, (max-width: 1362px) 62vw, 840px\" \/><figcaption>source:twitter.com<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">That brings us to <strong>TESTING<\/strong> for the virus. The classic curve informs who we should test and when. Early testing helps identify individuals with the virus so they can be <strong>isolated<\/strong> from the population at large. (Remember, <em>many of these people are not obviously sick.<\/em>) This is referred to as the <strong>Containment Phase<\/strong>. In the US we did not\/could not do adequate proactive testing due to a <strong>cascade of technical, regulatory, and political missteps<\/strong>. <a href=\"https:\/\/slate.com\/podcasts\/what-next-tbd\/2020\/03\/where-are-coronavirus-tests\" target=\"_blank\" rel=\"noreferrer noopener\" aria-label=\"[Link to More Info] (opens in a new tab)\">[Link to More Info]<\/a><\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"594\" height=\"680\" src=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/05-classic-epidemic-s-curve-annotated.jpg\" alt=\"\" class=\"wp-image-8629\" srcset=\"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/05-classic-epidemic-s-curve-annotated.jpg 594w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/05-classic-epidemic-s-curve-annotated-131x150.jpg 131w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/05-classic-epidemic-s-curve-annotated-218x250.jpg 218w\" sizes=\"auto, (max-width: 594px) 85vw, 594px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Failure to test<\/strong> enough of the right people early lead us to where we are now, <strong>Epidemic Spread<\/strong>. No one knows how far we will progress before the curve starts leveling off. <em>This is a scary place to be, a bit like looking over a cliff edge into the abyss.<\/em> The focus of testing is now on those who are ill, first responders, and healthcare workers at all levels.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Once we reach the point where <strong>the total number of new cases begins to drop<\/strong>, testing again becomes important to ensure containment, identify people who can go back to work, etc&#8230; This will also be the time to start a different sort of testing (for antibodies) to gauge <strong>who is immune<\/strong>, and who remains susceptible to new infection.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Epidemiologist&#8217;s Worst Nightmare<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">To help illustrate how the <strong>US Epidemic<\/strong> spread I&#8217;ll link to this <a rel=\"noreferrer noopener\" aria-label=\"fascinating video (opens in a new tab)\" href=\"https:\/\/youtu.be\/cq2zuE3ISYU\" target=\"_blank\">fascinating video<\/a> from a data visualization company. <em>They started with anonymous cell phone &#8220;ping&#8221; data from a small segment of beach in Fort Lauderdale during <\/em><strong><em>Spring Break<\/em><\/strong><em>.<\/em> <\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"298\" height=\"360\" src=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/07-spring-break-2020-beach-ft-lauderdale-techtonix.png\" alt=\"\" class=\"wp-image-8645\" srcset=\"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/07-spring-break-2020-beach-ft-lauderdale-techtonix.png 298w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/07-spring-break-2020-beach-ft-lauderdale-techtonix-124x150.png 124w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/07-spring-break-2020-beach-ft-lauderdale-techtonix-207x250.png 207w\" sizes=\"auto, (max-width: 298px) 85vw, 298px\" \/><figcaption>source:youtube.com<br \/><br \/><\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">As these <strong>few hundred individuals<\/strong> took themselves (and their phones) back home, look at the result (called a <strong>Heat Map<\/strong>)!<\/p>\n\n\n\n<figure class=\"wp-block-image\"><img loading=\"lazy\" decoding=\"async\" width=\"525\" height=\"363\" src=\"http:\/\/richard.rathe.org\/wp-content\/uploads\/2020\/03\/08-spring-break-2020-travel-usa-techtonix.png\" alt=\"\" class=\"wp-image-8646\" srcset=\"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/08-spring-break-2020-travel-usa-techtonix.png 525w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/08-spring-break-2020-travel-usa-techtonix-150x104.png 150w, https:\/\/redmangrove.org\/rathe.org\/richard\/wp-content\/uploads\/2020\/03\/08-spring-break-2020-travel-usa-techtonix-362x250.png 362w\" sizes=\"auto, (max-width: 525px) 85vw, 525px\" \/><figcaption>source:youtube.com<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>This is an epidemiologist&#8217;s worst nightmare!<\/strong> A similar scenario could be expected from this year&#8217;s <strong>Mardi Gras<\/strong>. <em>The Governors of Florida and Louisiana should both be held accountable for not closing these infection pipelines down!<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Around March 25 the US became the poster child for the COVID19 Pandemic. This graphic from the Financial Times Tracking Site tells the sad tale. America is again number one! =( Note that when I first blogged about COVID19 back on March 1st there were only 62 reported cases in the US! At the time &hellip; <a href=\"https:\/\/redmangrove.org\/rathe.org\/richard\/2020\/the-us-covid19-pandemic-and-s-curves\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;The US COVID19 Pandemic and S-Curves&#8221;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[129,22,28],"tags":[468,469,466,473,475,467,474],"class_list":["post-8613","post","type-post","status-publish","format-standard","hentry","category-commentary","category-medicine","category-science","tag-coronavirus","tag-covid19","tag-epidemic","tag-epidemiology","tag-florida","tag-pandemic","tag-united-states"],"_links":{"self":[{"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/posts\/8613","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/comments?post=8613"}],"version-history":[{"count":41,"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/posts\/8613\/revisions"}],"predecessor-version":[{"id":8668,"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/posts\/8613\/revisions\/8668"}],"wp:attachment":[{"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/media?parent=8613"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/categories?post=8613"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/redmangrove.org\/rathe.org\/richard\/wp-json\/wp\/v2\/tags?post=8613"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}